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Gene expression profiling and development of biomarkers

Nazwa przedmiotu: Profil ekspresji genów i rozwój biomarkerów. (Gene expression profiling and development of biomarkers) [0501-GEPM-DX]
Typ Przedmiotu: Wykład monograficzny.
Rok Studiów, kierunek, semestr: III lic oraz I, II, mgr
Liczba punktów, ECTS: 30 h Pkt ECTS 3/Z
Treści merytoryczne przedmiotu:
1. Introduction of cancer genome
2. Basic molecular biology of the cancer researches
3. Biomarker: The biologic predictor of disease progression
4. Cancer Biology and cancer Medicine
5. Cancer biomarkers (diagnostic, prognostic and predictive biomarkers)
6. Tissue biomarkers: the BioBank profiling
7. Antibodies based Discovery of biomarkers: (Gene expression profiling)
8. Antibodies based Discovery of biomarkers: (protein expression profiling)
9. Biomarkers in clinical research: What does it mean and how do I prepare?
10. Metabolic Disease Prevention: Nutrient Biomarker Study:
11. The Duke Clinical Research Institute (DCRI) Biomarker Compendium
12. DCRI Clinical Trials of Biomarker
13. Challenges for Drug Discovery in a Post genomic World:
14. Repairing DNA: Our Best Defense Against Cancer:
15. Molecular Profiling Diagnostics for Breast Cancer:

Linked to microarray Lecture

Cancer:

Basic Molecular Biology

Basic Biology:

Molecular Biology and Cancer Introuction

Biomarkers/Biologic Predictors of Disease Progression:

Cancer Biology and Cancer Medicine:

Part 1 of 6 Antibody based Biomarker Discovery in Cancer Research

Part 2 of 6 Antibody based Biomarker Discovery in Cancer Research

Part 3 of 6 Antibody based Biomarker Discovery in Cancer Research

Part 4 of 6 Antibody based Biomarker Discovery in Cancer Research

Part 5 of 6 Antibody based Biomarker Discovery in Cancer Research

Part 6 of 6 Antibody based Biomarker Discovery in Cancer Research

Biomarkers in clinical research: What does it mean and how do I prepare?

Metabolic Disease Prevention: Nutrient Biomarker Study:

DCRI Biomarker Compendium

DCRI Clinical Trials Biomarker RFA:

Challenges for Drug Discovery in a Postgenomic World:

Repairing DNA: Our Best Defense Against Cancer:

Molecular Profiling Diagnostics for Breast Cancer:

Gene expression profiling and development of biomarkers:
Genomics TV:
Lecture 1: National Human Genome Research Institute Director's Report to National Advisory Council, 9/13/10:
http://www.youtube.com/watch?v=fgVXn0iwwq8
Lecture 2: Introduction to 1000 Genomes Tutorial
http://www.youtube.com/watch?v=r3MyWWdWNSI
Lecture 3:Description of the 1000 Genomes data
http://www.youtube.com/watch?v=hKb2uh19kmI
Lecture 4: (1) Sequencing Human Genomes Circa 2010 (2) Clinical Annotation of Genomes:
http://www.youtube.com/watch?v=_vYOrz3Qu7o
Lecture 5: The Human Genome: A Decade of Discovery, Creating a Healthy Future (PM Session - Part 2):
http://www.youtube.com/watch?v=wfYYo1ASt2Y
Lecture 6: Focusing Genomics on Human Genetics
http://www.youtube.com/watch?v=uDJEq8j1Ul4
Lecture 7: Measurement of Genetic Exposure
http://www.youtube.com/watch?v=81J7p-HmZ3M
Lecture 8: Applications of Genetic Tools to Clinical and Translational Research
http://www.youtube.com/watch?v=X7sp1RrZLgs
Lecture 9: Course Overview and Introduction: The Biologic Basis for Analysis of Genetic Variants:
http://www.youtube.com/watch?v=J94RJSARUUw
lecture 10: Global Analysis of Transcriptional Regulation in Humans:
http://www.youtube.com/watch?v=EidTp61hQwY
Lecture 11: Webinar: The Long and Short of It: Finding Genes for Complex Traits In the Domestic Dog:
http://www.youtube.com/watch?v=jFixUxxkwu0
Lecture 12: Receiving and Distributing Genotype, Phenotype and Exposure Data in GWA Studies:
http://www.youtube.com/watch?v=-UljtP54Mb0
Letcure 13: Adventures in the Cancer Genome
http://www.youtube.com/watch?v=8rob8xeBpVE
Lecture 14: Common Disease Findings:
http://www.youtube.com/watch?v=UfVwCBXJZLA
lecture 15:Webinar: Planning for the Future of Genomics
http://www.youtube.com/watch?v=FXpDLH8s6Kk